Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Kiran Kumar Reddi
India
Research Article
Bioinformatic Analysis of Alzheimer’s Disease Using Functional Protein Sequences
Author(s): Allam Appa Rao, Kiran Kumar Reddi and Hanuman ThotaAllam Appa Rao, Kiran Kumar Reddi and Hanuman Thota
Alzheimer’s disease is a progressive neurodegenerative disorder characterized by deposition of amyloid plaques composed of aggr e- gated amyloid beta plaques, and neurofibrillary tangles composed of hyperphosphorylated tau that leads to synaptic defects resu lting in neuritic dystrophy and neuronal death. Missense mutations in amyloid precursor protein (APP), PS-1 (presenilin-1 situated on chromosome 14), PS-2 (presenilin-2 situated on chromosome 1) genes alter the proteolysis of APP and increase the generation of Aâ42 (amyloid â-42). The accumulation of Aâ42 as diffuse plaques triggers the inflammatory responses in the form of microglial activ ation and release of cytokines. In addition, perturbation of equilibrium between kinases and phosphatases results in hyperphosporylat ion of tau protein. These events culminate in neuronal degeneration and neuronal loss.. View More»
DOI:
10.4172/jpb.1000007