Journal of Alcoholism & Drug Dependence
Open Access

Kirti Parwani

Publications

• Review Article
  Association of Advanced Glycation End Products (AGEs) with Diabetic Nephropathy and Alcohol Consumption
  Author(s): Kirti Parwani, Palash Mandal Kirti Parwani, Palash Mandal
  
  The occurrence of diabetes is accelerating worldwide, with consequent increase in the secondary complication like diabetic nephropathy (DN). Diabetic nephropathy refers to a set of structural and functional abnormalities of kidney in patients with diabetes. Detrimental changes like glomerular hypertrophy, glomerulosclerosis, hyperfiltration, proteinuria, etc. occur in DN. One of the major pathways suggested for the pathogenesis is formation of Advanced Glycation End Products (AGEs) via non enzymatic glycation (NEG). NEG is the process in which reducing sugars irreversibly modify free amino groups of proteins, by various events leading to the formation of a Schiff base resulting in Amadori products, culminating into AGEs. AGEs activate several cascades of intracellular signaling via interaction with Receptor for AGEs (RAGE) that results in responses like release of pro-inflammatory cyt.. View More»
  DOI: 10.4172/2329-6488.1000290

  Abstract PDF

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