Journal of Drug Metabolism & Toxicology
Open Access

Klouz A

Publications

• Case Report
  PRES Induced by Cyclosporin with Normal Blood Concentrations in a Bone Marrow Recipient
  Author(s): Charfi R, Ben Sassi M, Gaies E, El Jebari H, Jebabli N, Lakhal M, Klouz A, Salouage I and Trabelsi SCharfi R, Ben Sassi M, Gaies E, El Jebari H, Jebabli N, Lakhal M, Klouz A, Salouage I and Trabelsi S
  
  Introduction: Posterior reversible encephalopathy syndrome (PRES) is a clinic neuroradiological entity. This syndrome occurs in complex conditions as allogenic bone marrow transplantation, organ transplantation and immunosuppressant therapy such as cyclosporin (CsA). The occurrence of PRES is favored by a high concentration of CsA. Therefore, therapeutic monitoring of CsA is necessary to effects due to overdose. The therapeutic range of CsA is between 150-300 ng/mL. We aimed to present a case PRES induced by CsA in bone marrow transplantation with normal cyclosporine blood concentrations. Case: A 26 years old man received an allogenic bone marrow for bone marrow aplasia in January 2013. He was treated by CsA. Mean CsA dose was 2.57 mg/kg/day. CsA mean blood concentration was 295 ng/mL. After 20 days, our patient presented a complex partial seizure and cortical abnormal. He had no hist.. View More»
  DOI: 10.4172/2157-7609.1000178

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