Journal of Nanomedicine & Biotherapeutic Discovery
Open Access

Koel Chaudhury

Publications

• Research Article
  Letrozole and Curcumin Loaded-PLGA Nanoparticles: A Therapeutic Strategy for Endometriosis
  Author(s): Saikat Kumar Jana,Baidyanath Chakravarty,Koel Chaudhury* Saikat Kumar Jana,Baidyanath Chakravarty,Koel Chaudhury*
  
  Clinical treatment of endometriosis, a common gynaecological disorder, still remains a challenge. Hormonal suppression, pain relief medication and surgical intervention are the conventional treatment modalities; however, frequent recurrence of the disease renders the results unsatisfactory. Given the fact that oxidative stress, angiogenesis, excessive matrix degradation, and aromatase activity are associated with endometriosis, we were motivated to use the combinatorial effect of two drugs, Curcumin (Cur) and Letrozole (Let) encapsulated in PLGA and test their efficacy in mice induced with the disease. The nanoparticles (NPs) were synthesized using solvent evaporation method and characterization indicated the spherical particles to be monodispersed, polymorphic, small in size with high encapsulation efficiency, without having a tendency for significant aggregation or .. View More»
  DOI: 10.4172/2155-983X.1000123

  Abstract PDF

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