Journal of Chromatography & Separation Techniques

Journal of Chromatography & Separation Techniques
Open Access

ISSN: 2157-7064

+44 1300 500008

Kogawa AC

Kogawa AC
Sao Paulo State University(UNESP),
Campus Araraquara, Rodovia Araraquara-Jaú, Km 1, CEP 14800-903, Araraquara, SP,
Brazil

Publications
  • Research Article
    Development and Validation of an Innovative and Ecological Analytical Method Using High Performance Liquid Chromatography for Quantification of Cephalothin Sodium in Pharmaceutical Dosage
    Author(s): Aleixa do Nascimento P, Kogawa AC* and Salgado HRN Aleixa do Nascimento P, Kogawa AC* and Salgado HRN

    Cephalothin is a first-generation cephalosporin, that shows great activity against Gram-positive microorganisms. Its effect is bactericidal, and due its action, it is the most efficient first-generation cephalosporin against resistant microorganism (β-lactamase producers). Although this drug has been clearly studied and researched about its antimicrobial activity, pharmacokinetics and pharmacodynamics, there are a few studies in literature regarding the development of analytical methodology for this cephalosporin. The aim of this work was to develop and validate a new method of analysis, using high performance liquid chromatography, resulting in an innovative method, quick and using solvents of low toxicity, minimizing, in this way, its toxic actions to the operators and leavings in the environment. The method developed and validated for the quantification of sodium cephalothin i.. View More»
    DOI: 10.4172/2157-7064.1000394

    Abstract PDF

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