Translational Medicine
Open Access

Kostadin Karagiozov

Publications

• Research Article
  Usefulness of the Behavior of Fibroblast Attachment to Coils in Thermoreversible Gelation Polymer for Aneurysmal Coil Treatment
  Author(s): Yuta Suzuki*, Mitsuyoshi Watanabe, Yuichi Murayama, Kostadin Karagiozov, Yoshinobu Manome and Hiroki Ohashi Yuta Suzuki*, Mitsuyoshi Watanabe, Yuichi Murayama, Kostadin Karagiozov, Yoshinobu Manome and Hiroki Ohashi
  
  Background: Post embolization aneurysm reccurence is still a drawback in endovascular coiling for cerebral aneuryms. That stimulated reaearch into new promising embolic materials, as the Thermoreversible Gelation Polymer (TGP) when used as cell culture medium with its temperature related properties. We evaluated proliferative properties of fibroblast cell cultures in association with metalic coils. Methods: Intial assessment of cell viability was done for 3T3 (mouse fibroblast) and A172 (glioma cell) lines for 6 and 16 days in TGP solid phase and media. After that TGP was liquified and cell attachment confirmed. Next, fibroblasts were cultivated under the same conditions adding Guglielmi detachable coils for 24 h and 3 days with TGP, evaluating cell attachment and proliferation on coils. Last, the time course of cell proliferation was evalua.. View More»
  DOI: 10.4172/2161-1025.1000167

  Abstract PDF

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