Biochemistry & Pharmacology: Open Access
Open Access

Krishnamoorthy P

Publications

• Research Article
  Effect of Vitamin C and Vitamin E on Mercuric Chloride-Induced Reproductive Toxicity in Male Rats
  Author(s): Muthu K and Krishnamoorthy P Muthu K and Krishnamoorthy P
  
  To evaluate the protective effects of Vitamin C and Vitamin E against Mercuric chloride -induced reproductive toxicity and to study the mechanisms underlying these effects. Male Wistar rats were orally administered mercuric chloride (10 mg/100 gm b.wt), (10 mg/100 gm b.wt) of mercuric chloride + (40 mg/100 gm b.wt) of Vitamin C and (10 mg/100 gm b.wt) of mercuric chloride + (20 mg/100 gm b.wt) of Vitamin E were administered orally to male albino rats for 30 days. Treatments with either Vitamin C or Vitamin E resulted in a significant protection of reproductive function. Both vitamins reduced the extent of mercuric chloride-induced reproductive toxicity, as evidenced by decrease in sperm abnormality and increase in sperm motility. Mercuric chloride-induced alterations in testis lipid peroxidation (MDA) were also markedly improved by test vitamins, and mercuric chloride -induced alterat.. View More»
  DOI: 10.4172/2167-0501.1000102

  Abstract PDF

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