Pancreatic Disorders & Therapy
Open Access

Kunal Mishra

Publications

• Mini Review
  CAR-T: The Current and the Future
  Author(s): Kunal Mishra, Shu-Feng Zhou and Jiazhi Sun Kunal Mishra, Shu-Feng Zhou and Jiazhi Sun
  
  Chimeric antigen receptors (CARs) are recombinant receptors that are expressed on autologous T-cells. CAR-T usage has grown in recent years as a way to combat hematological and solid tumors. The purpose of this review is to describe new studies on CAR-T treatment along with our lab’s ideas on potential uses and pitfalls that could be investigated. The usage of TREG and antiCLTA4 as means for regulating CAR-T will also be looked at along with OX40, CD137 and CD27 receptors as means for increasing the efficacy of the treatment overall. In addition the usage of iCasp9 as a ‘suicide switch’ for the CAR-T treatment and the potential for a 4th generation CAR will be touched upon. Then the review will lead into talks about how such a treatment could be of potential use in treating solid and hematological cancer. .. View More»
  DOI: 10.4172/2165-7092.1000154

  Abstract PDF

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