Journal of Bone Research
Open Access
ISSN: 2572-4916
+44 1478 350008
ISSN: 2572-4916
+44 1478 350008
LaRue AC
109 Bee1 Street, Research Services (151), Ralph H. Johnson VAMC, Charleston, SC 29403
Tanzania
Research Article
TGF-β1 Directs Chondrogenic Differentiation of Monocytic Precursor Cells
Author(s): Wilson KR, Kelly RK, Xiong Y, Cray JJ and LaRue AC
Wilson KR, Kelly RK, Xiong Y, Cray JJ and LaRue AC
Bone marrow consists of two types of stem cell populations, the hematopoietic stem cell (HSC) and the mesenchymal stromal cell (MSC). While MSCs have been demonstrated to have the capacity to differentiate into osteoblasts, chondrocytes, and adipocytes, recent studies by our laboratory have demonstrated an HSC origin for osteoblasts, cancer-associated fibroblasts, and immature adipocytes, revealing the ability of HSCs to give rise to cell types outside of the hematopoietic lineage. Previous in vivo studies in our laboratory using a clonal cell transplantation model, demonstrate the ability of HSCs to give rise to hypertrophic chondrocytes during nonstabilized fracture repair. This work has led to the hypothesis that the HSC is an alternate source for chondrocytes. To begin addressing this hypothesis, in vitro studies were performed to determine approp.. View More»
DOI:
10.4172/2572-4916.1000170