Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Laura Wisch
Tanzania
Research Article
Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease)
Author(s): Zhihui Xie, Eunice Chan, Yuzhi Yin, Chandra C. Ghosh, Laura Wisch, Celeste Nelson, Michael Young, Samir M. Parikh and Kirk M. DrueyZhihui Xie, Eunice Chan, Yuzhi Yin, Chandra C. Ghosh, Laura Wisch, Celeste Nelson, Michael Young, Samir M. Parikh and Kirk M. Druey
Objectives: The Systemic Capillary Leak Syndrome (SCLS) is a rare and potentially fatal disorder resembling systemic anaphylaxis that is characterized by transient episodes of hypotensive shock and peripheral edema. The pathogenesis of SCLS is unknown, and triggers for attacks are apparent only in a minority of patients. We introduce a clinical algorithm for the diagnosis of SCLS, and we investigated potential serum biomarkers of acute SCLS episodes.Methods: We analyzed serum cytokines in a cohort of 35 patients with an established diagnosis of SCLS and characterized the effects of SCLS sera on endothelial cell function. We investigated the cellular source(s) of CXCL10, a chemokine that was significantly elevated in both basal and acute SCLS sera, by flow cytometry.Results: Several cytokines were elevated in acute SCLS ser.. View More»
DOI:
10.4172/2155-9899.1000213