Immunome Research
Open Access
ISSN: 1745-7580
+44-77-2385-9429
ISSN: 1745-7580
+44-77-2385-9429
Lefebvre PP
Belgium
Brief Report
CX3CR1 Contributes to Nasal Neutrophilia in Airways Allergy: Novel Role
for IL-8 in Inducing CX3CR1Expression by Neutrophils
Author(s): Lejeune T, Roncontrati P, Lefebvre PP, Delvenne P, and El-Shazly AE
Lejeune T, Roncontrati P, Lefebvre PP, Delvenne P, and El-Shazly AE
Background: CX3CR1 is involved in promotion of inflammation by recruiting inflammatory cells to the inflamed tissue. However, no reports studied their expression by neutrophils infiltrating the nasal tissue in chronic rhinosinusitis (CRS) patients with or without associated airways allergy.
Objectives: Our objectives were to evaluate the expression of CX3CR1 by neutrophil infiltrating the inflamed nasal tissue in patients suffering from CRS, and to study the receptor gene induction in activated human neutrophils.
Methods: Immunohistochemistry were conducted to evaluate CX3CR1 expression by neutrophil cells infiltrating the middle turbinate from patients operated for endoscopic sinus surgery. The gene expression and the receptor surface expression in resting versus activated neurophils by IL-8 were studied by Q-PCR and fl.. View More»
DOI:
10.4172/1745-7580.1000161