Organic Chemistry: Current Research
Open Access

Lei Fu

Publications

• Research Article
  Synthesis and Antibacterial Activity Study of C-3 α, β-Unsaturated Ketone Linked Benzofuran Derivatives
  Author(s): Wenlu Liu, Xizhen Jiang, Wei Zhang, Faqin Jiang1 and Lei Fu Wenlu Liu, Xizhen Jiang, Wei Zhang, Faqin Jiang1 and Lei Fu
  
  Based on a benzofuran skeleton bearing aryl substituent at its C-3 position through an α, β-unsaturated ketone linker, twenty-one new compounds were chemically synthesized and biologically evaluated for their antibacterial activities against four bacteria, Escherichia coli, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, and Bacillus subtilis. Nine of the synthesized benzofuran derivatives exhibited antibacterial activities. Among them, compound 7e showed excellent MIC80 values from 0.78 to 1.56 μg/mL and was comparable to the positive control drugs. .. View More»
  DOI: 10.4172/2161-0401.1000164

  Abstract PDF

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