Endocrinology & Metabolic Syndrome
Open Access

Leonie K Callaway

Publications

• Review Article
  The Role of Irisin in Gestational Diabetes Mellitus: A Review
  Author(s): Charlotte Ramin, Helen L Barrett, Leonie K Callaway and Marloes Dekker NitertCharlotte Ramin, Helen L Barrett, Leonie K Callaway and Marloes Dekker Nitert
  
  Irisin is a newly described myokine that improves insulin resistance via the browning of white adipose tissue. Irisin appears to be secreted in response to exercise, providing a hormonal link between exercise and improved insulin sensitivity. Irisin expression has been demonstrated to increase after acute exercise and cold exposure in animal and human studies. Circulating irisin is decreased in metabolic disease states characterised by insulin resistance, such as type 2 diabetes mellitus, non-alcoholic fatty liver disease, chronic kidney disease and metabolic syndrome. The role of irisin in in normal pregnancy as well as gestational diabetes mellitus is yet to be fully elucidated. To date, there are inconsistent reports regarding the changes in circulating irisin that occur in pregnancy and Gestational Diabetes Mellitus (GDM). Overall, it appears that irisin levels increase with pregn.. View More»
  DOI: 10.4172/2161-1017.1000138

  Abstract PDF

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