Mycobacterial Diseases
Open Access

Lesibana Anthony Malinga

Publications

• Review Article
  Efflux Pump Mediated Second-Line Tuberculosis Drug Resistance
  Author(s): Lesibana Anthony Malinga, Anton Stoltz and Martie van der WaltLesibana Anthony Malinga, Anton Stoltz and Martie van der Walt
  
  The burden and spread of drug-resistant tuberculosis disease is a major public health problem worldwide. The causative agent, Mycobacterium tuberculosis uses several mechanisms to counteract therapy through drugresistance. A major and most common mechanism of drug-resistance is mediated through target mutations. Efflux pumps are emerging as potential agents of drug-resistance and treatment failure. In this review we explore the origin and principles of efflux pump-mediated resistance and determine their impact on second-line drugs used against extensively drug resistant tuberculosis. Inhibition of efflux pumps as a therapeutic intervention is also discussed... View More»
  DOI: 10.4172/2161-1068.1000222

  Abstract PDF

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