Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Lewandowski Krzysztof
Szamarzewskiego 82/84, Poznan
Poland
Case Report
IgG Monoclonal Immunoglobulin (M-protein) as Factor V Inhibitor in Multiple Myeloma Patient: Case Report and Discussion
Author(s): Lewandowski Krzysztof, Szczepaniak Tomasz, Dytfeld Dominik, WojtasiÃ
Âska Ewelina, Dziatkiewicz Paulina, Przysiecka Ã
Âucja, Borowczyk Martyna, PopÃ
Âawski Dariusz and Komarnicki MieczysÃ
ÂawLewandowski Krzysztof, Szczepaniak Tomasz, Dytfeld Dominik, WojtasiÅska Ewelina, Dziatkiewicz Paulina, Przysiecka Åucja, Borowczyk Martyna, PopÅawski Dariusz and Komarnicki MieczysÅaw
We present a case of a 53-year-old male with a symptomatic relapse of IgGλ multiple myeloma who was readmitted to the hospital with clinical symptoms of retroperitoneal hematoma. Laboratory tests revealed high concentration of monoclonal immunoglobulin G (32 g/l, 91.6% of total IgG) in the serum, prolongation of activated partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin time (TT), significantly decreased factor V procoagulant activity and the presence of factor V inhibitor. After successful retreatment with the use of six cycles of bortezomib, adriamycin and dexamethasone, the monoclonal IgG concentration in the patient’s serum significantly decreased (up to 1.3 g/l). At that time, also the normalization of the results of aPTT, PT and TT was stated. Therefore, the presence of factor V inhibitor in monoclonal immunoglobulin fraction was suspected. To c.. View More»
DOI:
10.4172/2155-9899.1000410