Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Li Jie
China
Research Article
Walker256 Sarcoma Stimulates Myocardial Angiogenesis after Acute Myocardial Infarction
Author(s): Liu Jian-gang, Zhang Da-wu, Zhang lei, Li Jie and Shi DazhuoLiu Jian-gang, Zhang Da-wu, Zhang lei, Li Jie and Shi Dazhuo
Objective: Regulating angiogenesis is an attractive target for treating tumors or ischemic diseases. The present study was to establish the Wister rat model with acute myocardial infarction (AMI) and Walker256 Sarcoma, and observe angiogenesis and expression of vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGFβ1).
Method and results: Wistar rats were randomly assigned to AMI group (subjected to coronary artery ligation), AMI-tumor group (right regioaxillaris tumor induced by inoculation of tumor cell after AMI), sham group (the operation procedure was same to AMI rats except for the ligation of coronary artery or tumor cell inoculation) and sham-tumor group (inoculation of tumor cell added to rats in sham group). The capillary density in myocardium was investigated with optical microscope, and protein.. View More»
DOI:
10.4172/2155-9880.1000396