Journal of Clinical Toxicology
Open Access

Li Xia

Publications

• Research Article
  Cochlear Cell Death Induced Via Cisplatin or Gentamycin in Combination with Furosemide in Rodents
  Author(s): Li XiaLi Xia
  
  Ototoxic models of animal represent an elemental tool in basic otological research. In the present study, using guinea pigs we compared cochlear lesions mediated via cisplatin applied in terms of two regimens: consecutive application alone and in combination with furosemide. The influences of furosemide alone were also assessed; it was observed to result in temporary hearing loss and reversible damage to the stria vascularis. Consecutive administration of cisplatin alone tended to be disadvantageous because it bred progressive body weight loss and higher mortality compared with the combined regimen, which utilized a smaller cisplatin dose. The combined regimen brought about remarkable hair cell loss without corresponding lesion of spiral ganglion neurons. This difference suggests that the co-administered regimen did not mimic the damage to cochlear neuronal innervation caused by clini.. View More»
  DOI: 10.4172/2161-0495.1000166

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