Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Lim Hwee Ying
Singapore
Review Article
Lipid Biology and Lymphatic Function: A Dynamic Interplay with Important Physiological and Pathological Consequences
Author(s): Lim Hwee Ying, Yeo Kim Pin and Angeli VeroniqueLim Hwee Ying, Yeo Kim Pin and Angeli Veronique
Lymphatic vessels have been traditionally considered as passive transporters of lipids particularly from the intestine. However, it became apparent from emerging research that lymphatic vessel can play a more extensive role in lipid metabolism than previously realized. Moreover, recent evidence reveals that lipid deposition in the form of white adipose tissue or cholesterol as observed in obesity or hypercholesterolemia, respectively, may perturb lymphatic function. This Review summarizes the evidence supporting a bidirectional relationship between lymphatic function and the deposition of white adipose or cholesterol in peripheral tissue in the context of obesity and hypercholesterolemia. We also discuss potential mechanisms whereby excessive fat or cholesterol accumulation in tissue may account for lymphatic dysfunction. We particularly consider how pheno.. View More»
DOI:
10.4172/2155-9899.1000261