Mycobacterial Diseases
Open Access

Lingaraja Jena

Publications

• Review Article
  Excretory Secretory Proteins Released during Growth of Mycobacterium tuberculosis (H37Ra), With Diagnostic Potential in Pulmonary and Extra Pulmonary Tuberculosis
  Author(s): Pranita Waghmare, Gauri Wankhade, Lingaraja Jena and Bhaskar C Harinath Pranita Waghmare, Gauri Wankhade, Lingaraja Jena and Bhaskar C Harinath
  
  TB immunodiagnostics based on antibody and antigen detection for early detection and monitoring tubercular infections at low cost and flexible to adapt to field laboratories are a boon to developing countries. In this context we have explored in-house developed penicillinase based ELISA assays for the detection of antigen, antibody as well as immune-complexed antigen using various excretory secretory antigenic proteins and specific antibodies. Excretory secretory protein antigens such as ES-31, ES-41, ES-43, ES-6, ES-20, ES-100 and EST-6 were studied extensively and found to be useful in various pulmonary and extra pulmonary cases of tuberculosis infection. ES-31 has shown its diagnostic potential in chronic PTB cases, ES-43 in relapse cases and ES-41 in bone and joint TB. Elevated level of ES-20 antigen was observed in patients with weak immune respo.. View More»
  DOI: 10.4172/2161-1068.1000215

  Abstract PDF

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