Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Lionel G Filion
Microbiology and Immunology,
451 Smyth Rd., Ottawa, ON K1H 8M5
Canada
Review Article
Vaccines against Mycobacterium Tuberculosis: Exploring Alternate
Strategies to Combat a Near-perfect Pathogen
Author(s): Lionel G Filion, Mohammed N Al-Ahdal and Jason A TetroLionel G Filion, Mohammed N Al-Ahdal and Jason A Tetro
Tuberculosis is a significant threat to human health, infecting nearly one third of the world’s population and causing over a million deaths per year. The need for an effective vaccine against tuberculosis is apparent however, the current vaccine has not been successful neither in the prevention nor recovery from infection. The pathogenesis of the causative agent, Mycobacterium tuberculosis has been extensively studied. The mechanisms of immune evasion and modulation that enable persistence of infection through subclinical latency and eventually active tuberculosis have been partially described. Many of these mechanisms are directly antagonistic to the intended benefit of vaccines, leaving a conundrum that has yet to be resolved. This review will first examine the nature of tuberculosis pathogenesis in the context of the immune response and outline the varied processes utilized .. View More»
DOI:
10.4172/2161-1068.S1-003