Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Lisbeth Berrueta
Instituto de Inmunología Clínica, Universidad de Los Andes,
Edificio Louis Pasteur, Merida
Venezuela
Research Article
Immune Modulators of HIV Infection: The Role of Reactive Oxygen Species
Author(s): Siham Salmen and Lisbeth BerruetaSiham Salmen and Lisbeth Berrueta
A continue loss of CD4+ T lymphocytes, immune response dysfunction and chronic immune activation (IA) are hallmarks of untreated chronic HIV-1 infection. ROS and the subsequent oxidative stress have been connected with chronic activation of the immune system, viral replication, immune dysfunction, programmed cell death, and neurological damage, all considered to be major contributing issues in HIV-1 diseases progression. It has been demonstrated that HAART partially restore the antioxidant capacity by suppressing HIV, and it has been suggested that antioxidant therapy in combination with HAART could protect the blood brain barrier from oxidative stressinduced damage. Several mechanisms have been proposed to explain how HIV could modulate ROS generation and several HIV proteins have been shown to modulate ROS production. This review is intended to highlight the role played b.. View More»
DOI:
10.4172/2155-9899.1000121