Chemotherapy: Open Access
Open Access

Liu H

Publications

• Research Article
  Claudin-7 Mediated Metastasis of Human Lung Adenocarcinoma Cells in Intermittent Hypoxia
  Author(s): Liu H, Li JY, Wang Y, Yang HA, Sun XY, Hu Y and Yan AH Liu H, Li JY, Wang Y, Yang HA, Sun XY, Hu Y and Yan AH
  
  Metastasis is a prerequisite for cancer development, which requires both proliferation and migration/invasion of the cancer cells. In this study, we reported that severe hypoxic conditions could inhibit the expression of HIF-1α and Claudin-7 and up-regulate the expression of p18 in human lung adenocarcinoma cells (A-549 cells). We demonstrated that hypoxic conditions can promote the metastasis, while inhibit the viability and proliferation of A-549 cells by downregulating HIF-1α/Claudin-7 and up-regulating p18. However, intermittent hypoxic condition could inhibit A-549 cells invasion and promote cell proliferation by affecting the expression of Claudin-7 and p18. We also confirm, using a small interfering RNA transfection technique (siRNA), that Claudin-7 could act as an anti-cancer biomarker of metastasis in A-549 cells. Silencing HIF-1α in A-549 cells could down-r.. View More»
  DOI: 10.4172/2167-7700.1000231

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