Clinical & Experimental Cardiology
Open Access

Lopez LR

Publications

• Review Article
  Atherosclerosis in Primary Antiphospholipid Syndrome: Summary of Clinical and Pathogenic Evidence
  Author(s): Ames PRJ, Lopez LR, Matsuura E and Margarita A Ames PRJ, Lopez LR, Matsuura E and Margarita A
  
  The Antiphospholipid Syndrome (APS) was described in the early ‘80s as a combination of thrombosis, thrombocytopenia and recurrent miscarriages associated with persistent high titers of Antiphospholipid Antibodies (aPL). In subsequent years, it became apparent that aPL were also associated with premature atherosclerosis in Systemic Lupus Erythematosus (SLE) and more recently in primary APS (PAPS). The studies exploring atherosclerosis in PAPS were heterogeneous in conception and size, but overall, provided enough evidence that Intima Media Thickness (IMT) of carotid arteries and endothelial function are abnormal in PAPS. In keeping with the general view that atherosclerosis is a low grade inflammatory and “auto”immune disorder characterised by oxidative and nitrative stress, several studies have confirmed similar findings in PAPS, though a specific relation with the .. View More»
  DOI: 10.4172/2155-9880.1000293

  Abstract PDF

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