Journal of Clinical & Experimental Dermatology Research
Open Access

Loubin Si

Publications

• Research Article
  Radiation Sensitization of Keloid Firboblasts by Quercetin through PI3K/Akt Pathway Dependent Regulation of HIF-1α
  Author(s): Loubin Si, Qin Han, Xiao Long, Fei Long, Robert Chunhua Zhao, Jiuzhuo Huang, Zhifei Liu, Ru Zhao, Hailin Zhang, Xiaojun WangLoubin Si, Qin Han, Xiao Long, Fei Long, Robert Chunhua Zhao, Jiuzhuo Huang, Zhifei Liu, Ru Zhao, Hailin Zhang, Xiaojun Wang
  
  Objective: Keloid is a benign tumor in the derma, which is generally treated by surgical excision and radiation in clinic. However, recurrence has been an intricate problem in treatment of keloid. Therefore, it is imperative to develop novel interfering means to increase the sensitivity of keloid to radiation. Quercetin is a natural compound, which has been shown to sensitize some tumors to radiation. We tested the potential of quercetin in sensitizing keloid fibroblast to radiation and identified its downstream pathways. Methods: Keloid fibroblast cells were challenged by radiation with or without the presence of quercetin. Cellular response was detected by flow cytometry, western blot, qRT-PCR and immunofluorescence staining. HIF-1α was down-regulated by siRNA transfection. Results: In this study, we firstly demonst.. View More»
  DOI: 10.4172/2155-9554.1000409

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