Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
+44 1223 790975
ISSN: 2155-9570
+44 1223 790975
Louis Tong
Singapore National Eye Center,
11, Third Hospital Avenue, 168751
Singapore
Research Article
Recent Advances: Transglutaminase in Ocular Health and Pathological Processes
Author(s): Louis Tong, Evelyn Png, Wanwen Lan and Andrea PetznickLouis Tong, Evelyn Png, Wanwen Lan and Andrea Petznick
Transglutaminase (TG) is a diverse class of crosslinking enzymes involved in the regulation of cytokine production, endocytosis, cell adhesion, migration, apoptosis and autophagy. It has been implicated in inflammatory diseases, neurodegenerative processes and cancer. The eye is a specialized organ which subserves the important function of vision and has distinctive physiological and anatomical properties that differ from other body tissues. Understanding of the roles of various TGs in the eye therefore require studies specific to cells and tissues of ocular origin. We review the advances in TG research in ocular diseases, including pterygium, glaucoma, cataract and proliferative vitreoretinopathy. TG1 is a molecule important for keratinisation in many cicatrizing diseases of the ocular surface, including keratoconjunctivitis sicca. TG2, with multiple functions, has been shown to be i.. View More»
DOI:
10.4172/2155-9570.S2-002