Pancreatic Disorders & Therapy
Open Access

Lourdes Robles

Publications

• Review Article
  Role of Oxidative Stress in the Pathogenesis of Pancreatitis: Effect of Antioxidant Therapy
  Author(s): Lourdes Robles, Nosratola D Vaziri and Hirohito Ichii Lourdes Robles, Nosratola D Vaziri and Hirohito Ichii
  
  Oxidative stress plays an important role in the pathogenesis of acute pancreatitis. The exact pathogenesis of pancreatitis remains unknown but several mechanisms related to oxidative and inflammatory stress are implicated. It is reasonable to surmise that antioxidants would play a protective role in ameliorating the deleterious effects of pancreatitis. We have a wealth of data from animal models that reveal a positive correlation between antioxidant drugs and improved outcomes in experimental pancreatitis. Human clinical trials with antioxidants however, have disclosed conflicting results. We review the existing pathogenesis of pancreatitis related to oxidative stress and provide of a review of current trials with antioxidant therapy. .. View More»
  DOI: 10.4172/2165-7092.1000112

  Abstract PDF

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