Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Lucie Kutikova
Director, Global Health Economics, Amgen Europe, Dammstrasse 23, PO Box 1557, CH-6301 Zug,
Switzerland
Research Article
Cardiovascular Disease and its Risk Factors in Patients with Familial Hypercholesterolemia: A Systematic Review
Author(s): Gregory Kruse, Lucie Kutikova, Bruce Wong, Guillermo Villa, Kausik K Ray, Pedro Mata and Eric Bruckert
Gregory Kruse, Lucie Kutikova, Bruce Wong, Guillermo Villa, Kausik K Ray, Pedro Mata and Eric Bruckert
Objectives: Familial hypercholesterolemia (FH) leads to prolonged vascular exposure to high levels of lowdensity lipoprotein cholesterol and subsequent development of atherosclerotic lesions. This study examines additional risk factors in patients with FH and their impact on cardiovascular disease (CVD) risk.
Methods: A systematic literature review identified publications describing cardiovascular risk in patients with FH (January-October 2016), extending a previous published review (2004-2015). Each article was assessed for bias by two reviewers using the modified Newcastle–Ottawa assessment scale for non-randomized studies. Additional risk factors studied included age, sex, FH mutations, and previous CVD.
Results: Three new studies were identified, conducted in the Netherlands, Spain, and Brazil, and review.. View More»
DOI:
10.4172/2155-9880.1000539