Chemotherapy: Open Access
Open Access

Luis Alexandre Muehlmann

Publications

• Research Article
  Effects of Photodynamic Therapy Mediated by Liposomal Aluminumphthalocyanine Chloride on Chemically Induced Tongue Tumors
  Author(s): João Paulo Figueiró Longo, Luis Alexandre Muehlmann, Nathália Vieira Velloso, Andreza Ribeiro Simioni, Silene Paulino Lozzi, Cláudio Eduardo de Oliveira Cavalcanti, Antônio Cláudio Tedesco and Ricardo Bentes de AzevedoJoão Paulo Figueiró Longo, Luis Alexandre Muehlmann, Nathália Vieira Velloso, Andreza Ribeiro Simioni, Silene Paulino Lozzi, Cláudio Eduardo de Oliveira Cavalcanti, Antônio Cláudio Tedesco and Ricardo Bentes de Azevedo
  
  Human oral squamous cell carcinoma is one of the ten most frequently diagnosed cancer types and several researches are thus focused on improving therapeutic protocols against this disease. Particularly, photodynamic therapy has emerged as an effective treatment for oral carcinoma. It is mediated by a photosensitizer, a molecule that, after being light-activated, promotes the chemical reactions responsible for the production of cytotoxic species involved in photodynamic therapy. Despite of clinical approvals, several classical photosensitizers present important drawbacks. However, when associated to liposomes, these drugs have been shown to present improved characteristics, such as increased tumor accessibility and high photodynamic activity in physiological media. Therefore, this work aimed to investigate the effects of photodynamic therapy mediated by a liposomal formulation of alumi.. View More»
  DOI: 10.4172/2167-7700.1000103

  Abstract PDF

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