Clinical & Experimental Cardiology
Open Access

Lupton H

Publications

• Research Article
  Activation of Hypoxia-Inducible Factor by Di-Methyl Oxalyl Glycine (DMOG) Increases Neovascularization within Ischaemic Myocardium in a Porcine Coronary Artery Occlusion Model
  Author(s): D J S Kelly, A C Morton, N D Arnold, J Mecinovic, C Schofield, H Lupton, K Al-Lamee, D C Crossman, J Gunn and A GershlickD J S Kelly, A C Morton, N D Arnold, J Mecinovic, C Schofield, H Lupton, K Al-Lamee, D C Crossman, J Gunn and A Gershlick
  
  Introduction: Chronic total coronary artery occlusion (CTO) in man remains a significant challenge for percutaneous coronary intervention (PCI) and a common reason for coronary artery bypass surgery, as often the CTO cannot be crossed. This study investigated whether a potential angiogenic treatment, the prolyl-4-hydroxylase inhibitor, di-methyl oxalyl glycine (DMOG), would increase collateral vessel formation and myocardial perfusion without opening the CTO in a porcine model of coronary CTO. Methods: We assessed the effect of DMOG upon tube formation of HUVEC in a matrigel assay in vitro. DMOG was loaded onto a polymer-coated coronary stent. Copper-coated stents were used to produce a coronary CTO in 20 pigs. DMOG-loaded or control stents were implanted in an alternating, blinded manner at day 28, proximal to the CTO. Angiographic and.. View More»
  DOI: 10.4172/2155-9880.1000148

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