Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
M Rita I Young
Research Service (151), Ralph H. Johnson VA Medical Center,
109 Bee Street, Charleston, SC 29401
Tanzania
Research Article
An Inflammatory Cytokine Milieu is Prominent in Premalignant Oral Lesions, but Subsides when Lesions Progress to Squamous Cell Carcinoma
Author(s): Danielle Woodford, Sara D Johnson, Anna-Maria A De Costa and M Rita I YoungDanielle Woodford, Sara D Johnson, Anna-Maria A De Costa and M Rita I Young
While head and neck squamous cell carcinomas (HNSCC) are associated with profound immune suppression, less is known about the immunological milieu of premalignant oral lesions. The present study shows dynamic shifts in the immune milieu within premalignant oral lesions and when they have progressed to HNSCC. Specifically, this study showed that the premalignant lesion environment consists of inflammatory mediators and IL-17, but this inflammatory phenotype declines when premalignant oral lesions have progressed to HNSCC. The cytokine profiles of human tissues did not correspond with plasma cytokine profiles. A murine carcinogen-induced premalignant lesion model that progresses to HNSCC was used to examine cytokine profiles released from tissues as well as regional lymph nodes. As in human tissues, murine premalignant lesions and regional lymph nodes released high levels of inflammator.. View More»
DOI:
10.4172/2155-9899.1000230