Journal of Cell Science & Therapy
Open Access

Magdalena Awsiuk

Publications

• Research Article
  Humanin Peptides Regulate Calcium Flux in the Mammalian Neuronal, Glial and Endothelial Cells under Stress Conditions
  Author(s): Anna Knapp, Urszula Czech, Anna Polus, Monika Chojnacka, Agnieszka Sliwa, Magdalena Awsiuk, Barbara Zapala, Dominika Malinska, Adam Szewczyk and Aldona Dembinska-KiecAnna Knapp, Urszula Czech, Anna Polus, Monika Chojnacka, Agnieszka Sliwa, Magdalena Awsiuk, Barbara Zapala, Dominika Malinska, Adam Szewczyk and Aldona Dembinska-Kiec
  
  "Humanin (HN) and humanin-like substances are short polypeptides that prevent neuronal cell death and dysfunction related to progression of Alzheimer?s disease. HN activates oligomeric receptor (CNFTR/WSX-1/gp130 complex) in the extracellular environment, and it is believed to interact with intracellular proteins, such as Bcl2 family. HN stimulates JAK2/STAT3 pathway that regulates apoptosis and cell death, however exact molecular mechanism of HN mediated cytoprotection remains unknown. The goal of our study was to evaluate effect HN (HNM) and HN-like peptides, which include HNG, HN10d and HN 10dV, on the intracellular calcium release in the cultured brain cells (LN18, C8D1A) and endothelial HUVECs under stress conditions. We incubated the cells with low amounts of HN (4 ?M) for 24 hours, generated cellular stress by addition of either 25 ?M β-amyloid (neuronal and glial cel.. View More»
  DOI: 10.4172/2157-7013.1000128

  Abstract PDF

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