Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Maha Zaki Rizk
Egypt
Review Article
Role of Gut-Brain Axis in the Aetiology of Neurodevelopmental Disorders with Reference to Autism
Author(s): Afaf El-Ansary, Ghada H. Shaker and Maha Zaki RizkAfaf El-Ansary, Ghada H. Shaker and Maha Zaki Rizk
Neurodevelopmental disorders, especially in children, result in brain and nervous system damage. These may result from environmental contaminants, intrauterine environment, infectious diseases or exposure to nanoparticles that cross the blood brain barrier. Gut microbiota directly influence the immune system, nervous system and brain development during microbial colonisation of the newborn (microbiota gut-brain axis) and are controlled and modulated by different endogenous and exogenous factors. Of these factors feeding with human milk creates a healthy microbiota in the infant gut and reduces incidence and severity of infections and promotes normal gastrointestinal function. In addition there is a direct correlation between maternal vaginal and intestinal bacteria, gut microbiota composition, and increased rates of obesity, metabolic and neuropathological disorders such as autism. Gu.. View More»
DOI:
10.4172/2161-0495.S6-005