Immunome Research
Open Access

Mahmoud SM

Publications

• Research Article
  Immunoinformatics Predication and Modelling of a Cocktail of B- and T-cells Epitopes from Envelope Glycoprotein and Nucleocapsid Proteins of Sin Nombre Virus
  Author(s): Idris AB, Mahmoud SM, Mohamed Elamin S, Mustafa YY, Osman AA, Adam ME, Ali LB, Abbas MH, Abu-haraz AH, Abdelrahman KA and Salih MA Idris AB, Mahmoud SM, Mohamed Elamin S, Mustafa YY, Osman AA, Adam ME, Ali LB, Abbas MH, Abu-haraz AH, Abdelrahman KA and Salih MA
  
  Sin Nombre virus is a category A pathogen with a reported mortality rate ranging from 30% to 50%. It was responsible for the 2012 Yosemite National Park outbreak. Until now, Specific therapy is not available for the treatment of HCPS caused by SNV. Despite many efforts to develop safe and effective vaccines against SNV, included conventional approaches as well as molecular vaccine approaches, to date there are no vaccines proven to be highly efficacious against SNV. In our study, we analyzed envelope glycoprotein and nucleocapsid of SNV by using immunoinformatics tools housed in IEDB resources; in order to determine the most conserved and immunogenic epitopes for B- and T-cells. Then the predicted epitopes were assessed for the population coverage against the whole world population with the MHC-I and MHC-II restricted alleles. Among predicted epitopes for B-cell, the best candidates f.. View More»
  DOI: 10.4172/1745-7580.1000141

  Abstract PDF

Relevant Topics