Journal of Leukemia
Open Access

Mahmut Yeral

Publications

• Case Report
  Association of Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia in Three Patients: Cases with the Concomitant Presence of Two Different Malignant Clones
  Author(s): Heba A Ahmed, Shereen P Aziz and Abeer HassanHeba A Ahmed, Shereen P Aziz and Abeer Hassan
  
  In this report we present three patients who are 70, 50 and 55 years of ages with complaints of fatigue, pallor, weakness and epistaxis. The Peripheral Blood (PB) smear and bone marrow aspiration (BMA) showed circulating blast cells, lymphocytes, and smudge cells. In first and second cases flow cytometric (FC) analysis demonstrated that blasts were associated with co-expression of Chronic Lymphocytic Leukemia (CLL) and Acute Myeloid Leukemia (AML) immunophenotyping. In the third case Bone Marrow Biopsy (BMB) showed megaloblastic and dysplastic changes in eryhtroid, megakaryocytic and myeloid lineages. The concomitant occurrence of AML and CLL might be a common stem cell defect, a consequence of leukomogenic factors or a genetic predisposition in some patients. CLL development after the diagnosis of Myelodysplastic Syndrome (MDS) or AML was not reported in the literature. From thi.. View More»
  DOI: 10.4172/2329-6917.1000250

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