Translational Medicine
Open Access

Makoto Shoji

Publications

• Review Article
  Stem/Progenitor-Cell-Based Approach for Restenosis after Percutaneous Coronary Intervention: Application of Bone Marrow Progenitors and Future Perspectives
  Author(s): Yoshitaka Iso, Takuya Watanabe, Makoto Shoji and Hiroshi Suzuki Yoshitaka Iso, Takuya Watanabe, Makoto Shoji and Hiroshi Suzuki
  
  Endothelial dysfunction and cell loss are prominent features of cardiovascular disease. Endothelial damage is a critical trigger of restenosis after percutaneous coronary angioplasty or stent implantation. Consequently, rapid re-endothelialization is essential for restoring normal vascular function and regulating neointimal hyperplasia. Bone-marrow-derived cell therapy has emerged as a therapeutic option for the treatment of ischemic cardiovascular diseases by virtue of its effects in enhancing endothelial capillary growth and collateral formation. It remains to be seen whether this cell therapy is also effective for the treatment of restenosis, but evidence suggests that it may be. Bone marrow stem/progenitor cells promote endothelialization and modulate immune response, processes that can lead to vascular repair after injury. Given the increased concern over late thrombosis after dr.. View More»
  DOI: 10.4172/2161-1025.S7-001

  Abstract PDF

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