Reproductive System & Sexual Disorders: Current Research
Open Access

Malmir M

Publications

• Research Article
  Protective Antioxidant Effects of N-acetylcysteine on Testicular Tissue and Serum Testosterone in Paranonylphenol-Treated Mice (A Stereological Analysis)
  Author(s): Malmir M, Faraji T, Naderi Noreini S and Soleimani Mehranjani MMalmir M, Faraji T, Naderi Noreini S and Soleimani Mehranjani M
  
  Paranonilphenol (p-NP) is an environmental pollutant that affects the male reproductive system through induction of oxidative stress. The aim of this study was to evaluate the protective effects of N-acetylcysteine (NAC) as an antioxidant against impairment of testicular tissue caused by p-NP. In this study, 24 adult male NMRI mice were randomly divided into 4 groups (n=6 each groups): 1-Control, 2- p-NP (250 mg/kg/day), 3-NAC (150 mg/kg/day) and 4-p-NP+NAC. After 35 days of orally treatment a significant decrease in the diameter (P<0.01), germinal epithelium height (P<0.04), basement membrane thickness and volume of seminiferous tubules (P<0.02) and as well as a significant decrease in serum testosterone level (P<0.04) were observed. Also a significant decrease in the count of sertoli (P<0.04), leydig (P<0.02), spermatogonia (P<0.04), spermatocyte (P<0.04), ro.. View More»
  DOI: 10.4172/2161-038X.1000225

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