Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Manas Ranjan Dikhit
India
Research Article
Homology Modeling and Functional Analysis of LPG2 Protein of Leishmania Strains
Author(s): Ganesh Chandra Sahoo, Manas Ranjan Dikhit, Mukta Rani and Pradeep Das
Ganesh Chandra Sahoo, Manas Ranjan Dikhit, Mukta Rani and Pradeep Das
As drug resistance problem persists in case of Leishmaniasis, modeling and analysis of different essential proteins of Leishmania strains will help us further to discover novel lead compounds. Lipophosphoglycan 2 (LPG2) protein is required for the development of Leishmania throughout their life cycle, including for virulence to the mammalian host. LPG2 participates in a specialized virulence pathway, which may offer an attractive target for chemotherapy. Homology models of LPG2 of five Leishmania species have been constructed using the X-ray structures of different transporter proteins as templates, by comparative protein modeling principles. The resulting model has the correct stereochemistry as gauged from the Ramachandran plot and good three-dimensional (3-D) structure compatibility as assessed by the Procheck and Profiles-3D scores. Functional assignment of LPG2 p.. View More»
DOI:
10.4172/jpb.1000059