Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Mandakini B Patil
Nagpur-440033
India
Research Article
Investigations into the Immunostimulatory Activities of the Compounds Isolated from Zizyphus mauritiana
Author(s): Suhas Talmale, Arti Bhujade and Mandakini B PatilSuhas Talmale, Arti Bhujade and Mandakini B Patil
Objective: Any lacuna in the immune system can cause serious problems. Many synthetic immunostimulators are available, but they show many side effects. Phytochemicals present in Zizyphus mauritiana, Lam (Rhamnaceae) can act as natural immunostimulators. In the present study, natural and potent immunostimulatory compounds were isolated from Zizyphus mauritiana and their immunostimulatory activities were studied. Methods: Extracts of the stem bark were prepared in various solvents in the increasing order of polarity. These extracts were tested for their potential to stimulate phagocytosis. Ethanolic extract of stem bark, which was found to be effective in stimulating phagocytosis in macrophages, was further purified by adsorption column chromatography to get effective fraction termed as effective immunostimulatory fraction (EIF). EIF was t.. View More»
DOI:
10.4172/2155-9899.1000357