Journal of Clinical Trials
Open Access

Manfaluthy Hakim

Publications

• Research Article
  Improvement of Quality of Life in Patients with Peripheral Neuropathy Treated with a Fixed Dose Combination of High-Dose Vitamin B1, B6 and B12: Results from a 12-week Prospective Non-interventional Study in Indonesia
  Author(s): Manfaluthy Hakim, Nani Kurniani, Rizaldy Pinzon, Dodik Tugasworo, Mudjiani Basuki, Hasnawi Haddani, Pagan Pambudi, Aida Fithrie and Audry Devisanty WuysangManfaluthy Hakim, Nani Kurniani, Rizaldy Pinzon, Dodik Tugasworo, Mudjiani Basuki, Hasnawi Haddani, Pagan Pambudi, Aida Fithrie and Audry Devisanty Wuysang
  
  Objective: The 12-week prospective, non-interventional study conducted in Indonesia aimed to evaluate the effectiveness and safety of a fixed combination of high-dose vitamin B1, B6 and B12 in subjects with peripheral neuropathy (PN) of various etiology. As PN is known to significantly impair patients’ quality of life (QoL), special attention has been paid to this aspect and QoL data were collected as secondary outcome parameters over time. Methods: The study enrolled subjects aged 18–65 years with mild or moderate PN of various etiologies. PN symptoms were measured by Total Symptom Score (TSS) and Visual Analogue Scale (VAS) at visit 1 (baseline), visit 2 (day 14), visit 3 (day 30), visit 4 (day 60), and visit 5 (day 90). At visits 1, 3, 4, and 5, the subjects also reported QoL data as assessed by the Short Form 8 (SF-8) Health Survey Questionnaire. Changes from baseline to .. View More»
  DOI: 10.4172/2167-0870.1000343

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