Journal of Cell Science & Therapy
Open Access

Manfred Richter

Publications

• Research Article
  OSM-Stimulated Cardiomyocytes Release a C-Terminal Fragment of FGF23
  Author(s): Ranganath Maringanti, Thomas Kubin, Ayse Cetinkaya, Markus Schönburg, Andres Beiras- Fernandez, Thomas Braun, Thomas Walther, Sawa Kostin and Manfred Richter Ranganath Maringanti, Thomas Kubin, Ayse Cetinkaya, Markus Schönburg, Andres Beiras- Fernandez, Thomas Braun, Thomas Walther, Sawa Kostin and Manfred Richter
  
  Background: Recent studies emphasize a correlation of increased FGF23 with the pathogenesis of heart diseases. Although it is widely assumed that the bone and not the heart is the major source of FGF23 we previously demonstrated that oncostatin M (OSM) activated cardiomyocytes strongly secrete FGF23. This phosphatonin can be released as intact molecule (iFGF23) as well as C-terminal (cFGF23) and N-terminal (nFGF23) fragments. Since cleavage does not only inactivate iFGF23 but might also exert antagonizing activity we wanted to determine which form is secreted by cardiomyocytes. Methods: Adult cultured cardiomyocytes were stimulated with OSM or albumin as control. Supernatant and cell lysate were analyzed by Western blot (WB) and specific ELISAs against cFGF23 as well as iFGF23. Expression of FGF23 in cardiomyocytes of 6 patients with coronar.. View More»
  DOI: 10.4172/2157-7013.1000273

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