Translational Medicine
Open Access

Manju Ray

Publications

• Editorial
  Cancer Stem Cells, Wnt, Hedgehog and Notch Signaling, the Role of Dietary Phytochemicals: New Insights for Cancer Therapy
  Author(s): Anirban Roy, Manju Ray and Kuladip JanaAnirban Roy, Manju Ray and Kuladip Jana
  
  Therapy resistance and relapse is the worst prognostic outcome of cancer and is attributed to the presence of cancer stem cells in the tumor mass. Cancer stem cells survive the cytotoxic effects of commonly used chemotherapeutic drugs and radiation which targets and eradicates non cancer stem cells reducing the tumor bulk but is unable to stop tumor recurrence. Cancer stem cells re-initiate the evolutionary conserved embryonic signaling pathways such as Wnt, Hedgehog and Notch thereby endowing themselves with properties of pluripotency, self renewal and maintenance, activate DNA damage repair systems opposing effects of radiation and express energy driven drug efflux pumps expelling chemothepeutic drugs. Development of new therapeutic strategies aiming self sustained, self renewed, apoptosis surviving, aberrantly proliferating therapy resistant cancer stem cells and minimizing lon.. View More»
  DOI: 10.4172/2161-1025.1000e125

  Abstract PDF

Relevant Topics