Journal of Clinical Trials
Open Access

Manoussos Christodoulakis

Publications

• Protocol
  Preparation with Mechanical Bowel Cleansing or/and Oral Antibiotics or Nothing for Elective Colorectal Surgery: Two-Two-Arm Multicentre Randomised Controlled Studies (MECCLANT –C and –R Trials)
  Author(s): Evaghelos Xynos, Nikolaos Gouvas, Christos Agalianos, Ioannis Balogiannis, Manoussos Christodoulakis, Dimitrios Korkolis, Dimitrios Manatakis, Dimitrios Lytras, Ioannis Papakonstantinou, Costas Stamou, Ioannis Triantaphyllidis, Georgios Tzovaras and Georgios ZacharioudakisEvaghelos Xynos, Nikolaos Gouvas, Christos Agalianos, Ioannis Balogiannis, Manoussos Christodoulakis, Dimitrios Korkolis, Dimitrios Manatakis, Dimitrios Lytras, Ioannis Papakonstantinou, Costas Stamou, Ioannis Triantaphyllidis, Georgios Tzovaras and Georgios Zacharioudakis
  
  Background: Based on sound evidence, traditional mechanical bowel preparation for elective colorectal surgery has mostly been abandoned during the last two decades. However, more recent evidence from USA large databases show that mechanical bowel preparation combined with oral antibiotics, reduces significantly surgical site infections (SSI) after elective colorectal surgery. Hypothesis-Aim: We hypothesise that administration of oral antibiotics only, and not mechanical bowel preparation, is the main factor that prevents SSI. Furthermore, we consider that rectal surgery for cancer differs from colon surgery in that the former is usually associated with defunctioning stoma, which requires an empty colon. Patients-Methods: Patients to be subjected to elective colectomy for colonic neoplasms or diverticular disease will be randomised to two arms; Arm A: no bowel preparation; Arm B: mecha.. View More»
  DOI: 10.4172/2167-0870.1000300

  Abstract PDF

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