Journal of Clinical and Cellular Immunology
Open Access

Manuel Serrano

Publications

• Research Article
  Donor Chimerism, Kir Ligand Mismatch and Cytokine Levels (Tnfα, Il17, Gmcsf, l1β) and their Association with Graft Rejection in Liver Transplant Recipients
  Author(s): Rosa Ayala, Inmaculada Rapado, Antonio Perez, Silvia Grande, Alicia Arenas, Alvaro García Sesma, Jose Luis Vicario, Manuel Serrano, Jose Angel Martinez, Santiago Barrio, Carmelo Loinaz, Carlos Jimenez, Enrique Moreno and Joaquin Martinez-LopezRosa Ayala, Inmaculada Rapado, Antonio Perez, Silvia Grande, Alicia Arenas, Alvaro García Sesma, Jose Luis Vicario, Manuel Serrano, Jose Angel Martinez, Santiago Barrio, Carmelo Loinaz, Carlos Jimenez, Enrique Moreno and Joaquin Martinez-Lopez
  
  Background: The aim of the study is to design a predictive model of graft rejection in liver transplant recipients based on donor chimerism (DC) quantification, functional study of Natural Killer cells and cytokine levels. Methods: Seventy-four liver transplant recipients and their respective donors were studied, providing a total of 468 post-transplantation samples in the chimerism study. A total of 23 Liver Transplant patients and their respective donors took part in HLA typing and KIR genotyping, phenotyping, and cytotoxicity studies. 62 liver transplant recipients were analyzed in this cytokine study (62 pre-transplant and 109 post-transplant serum samples). Chimerism study was carried out by quantitative real time PCRs and 7 indels and 14 SNPs were detected with TM probes. A study of NK-cell subsets was performed on fresh samples by multip.. View More»
  DOI: 10.4172/2155-9899.1000407

  Abstract PDF

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