Journal of Clinical Toxicology
Open Access

Manuela Martins-Green

Publications

• Research Article
  THS Toxins Induce Hepatic Steatosis by Altering Oxidative Stress and SIRT1 Levels
  Author(s): Cristina Flores, Neema Adhami and Manuela Martins-GreenCristina Flores, Neema Adhami and Manuela Martins-Green
  
  Background: Third hand smoke (THS) forms when second hand smoke (SHS) tobacco toxins accumulate on surfaces such as walls, carpets and clothing and can result in adverse health effects. Objective: This study was designed to investigate the mechanism of THS-induced hepatic steatosis. Methodology: We used an in vivo exposure system that mimics exposure of humans to THS to investigate the effects of THS on hepatic lipid metabolism. THS-exposed mice were treated either with the liver-damaging drug, Nacetyl- p-aminophenol (APAP/Tylenol) to increase oxidative stress or with the antioxidants N-acetyl-cysteine and α- Tocopherol which decrease oxidative stress. Results: THS-exposed mice have higher levels of superoxide dismutase activity and H2O2 levels. However, no significant changes in activity of the antioxidant enzymes catalase and glutathione peroxidase were found, implying the pre.. View More»
  DOI: 10.4172/2161-0495.1000318

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