Journal of Clinical Toxicology
Open Access

Manuela Martins-Green

Publications

• Research Article
  The Role of Fatty Acid Metabolism and Apolipoproteins in Ths-Induced Hepatic Steatosis in Mice
  Author(s): Cristina Flores, Neema Adhami and Manuela Martins-Green Cristina Flores, Neema Adhami and Manuela Martins-Green
  
  Background: Hepatic steatosis results from the increase of accumulation of lipids in the liver, decrease of beta fatty acid oxidation and/or decrease in the export to peripheral tissue by apolipoproteins. Previously, we showed that third hand smoke (THS) toxins result in hepatic steatosis in mice. Objective: The goal of this paper was two-fold: (1) To determine whether THS toxins alter key molecules involved in beta fatty acid metabolism and (2) to determine whether the levels of apolipoprotein B is decreased in THS-exposed mice leading to decrease export of lipid from the liver. Methodology: Mice were exposed to THS toxins for 6 months before performing the studies shown here. THS-exposed mice were also placed on western diet (WD) for five months or treated with AICAR to determine how THS-toxins affect the lipid m.. View More»
  DOI: 10.4172/2161-0495.1000359

  Abstract PDF

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