Clinical & Experimental Cardiology
Open Access

Marco A Cardoso

Publications

• Research Article
  Cardiac Analysis of Autologous Transplantation of Cocultured Skeletal Myoblasts and Mesenchymal Cells in a Rat Model Doxorubicin-Induced Cardiotoxicity: Histopathological and Functional Studies
  
  Author(s): Cristiane Dias, Julio C Francisco, Marco A Cardoso, Ricardo C Cunha, Rossana B Simeoni, Bassam F Mogharbel, Nelson I Miyague, José R Faria-Neto, Cristina P Baena, Katherine AT Carvalho and Luiz C Guarita-Souza Cristiane Dias, Julio C Francisco, Marco A Cardoso, Ricardo C Cunha, Rossana B Simeoni, Bassam F Mogharbel, Nelson I Miyague, José R Faria-Neto, Cristina P Baena, Katherine AT Carvalho and Luiz C Guarita-Souza
  
  Objective: Investigate the functional and histopathological effects of combined transplantation of mesenchymal stem cells (MSCs) and skeletal myoblasts (SM) in rats submitted to doxorubicin (DOX) induced cardiomyopathy. Methods: Myocardiopathy was induced through intraperitoneal applications of 3.75 mg/kg/day DOX once a week for 4 weeks in all experimental animals. Echocardiography examination was conducted to evaluate heart function. Myocardial cell apoptosis was examined morphologically by optical microscopy. The expression of both, von Willebrand factor and MyoD proteins was analysed using immunohistochemical staining. Results: Our results showed that all the experimental animals developed cardio-toxicity and exhibited decrease in heart function 4 weeks after the administration of DOX (P<0.05). The ventricula.. View More»
  DOI: 10.4172/2155-9880.1000407

  Abstract

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