Clinical & Experimental Cardiology
Open Access

Marco A Cardoso

Publications

• Research Article
  Attenuation of Hindlimb Ischemia after Associated Autologous Transplantation of Bone Marrow Mononuclear Cells and Platelet Rich Plasma
  Author(s): Paulo RB Simeoni, Julio C Francisco, Rossana B Simeoni, Marco A Cardoso, Ricardo C Cunha, Bassam F Mogharbel, Joao C Minozzo, Vivian F do Amaral, José R Faria-Neto, Katherine AT Carvalho and Luiz C Guarita-Souza Paulo RB Simeoni, Julio C Francisco, Rossana B Simeoni, Marco A Cardoso, Ricardo C Cunha, Bassam F Mogharbel, Joao C Minozzo, Vivian F do Amaral, José R Faria-Neto, Katherine AT Carvalho and Luiz C Guarita-Souza
  
  Objective: The purpose of this study was to determine whether autologous bone marrow mononuclear stem cell (BMCs) associated with platelet rich plasma (PRP) transplantation improves peripheral collateralization in a rabbit ischemic limb model. Methods: Unilateral hindlimb ischemia was surgically induced in New Zealand White rabbits (n=30). A total of 106 BMCs+PRP were intramuscularly implanted into each ischemic limb. Blood flow was monitored by Doppler in the ischemic and control animals. Histological analysis of capillary density in the ischemic limbs was performed 30 days after the ischemia induction. Results: Histological sections of ischemic gastrocnemius muscle showed that capillary index (capillary/muscle fiber) was greater in the BMCs+PRP implantation group 30 days after the ischemia induction than in the s.. View More»
  DOI: 10.4172/2155-9880.1000409

  Abstract PDF

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