Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Marco WJ Schreurs
England
Research Article
IgE Cross-Reactivity Measurement of Cashew Nut, Hazelnut and Peanuts using a Novel Immulite Inhibition Method
Author(s): Shanna Bastiaan-Net, Manou R Batstra, Nasrin Aazamy, Huub FJ Savelkoul, Johanna PM van der Valk, Roy Gerth van Wijk, Marco WJ Schreurs, Harry J Wichers and Nicolette W de JongShanna Bastiaan-Net, Manou R Batstra, Nasrin Aazamy, Huub FJ Savelkoul, Johanna PM van der Valk, Roy Gerth van Wijk, Marco WJ Schreurs, Harry J Wichers and Nicolette W de Jong
Background: Tree nut allergic individuals are often sensitised towards multiple nuts and seeds. The underlying cause behind a multi-sensitisation for cashew nut, hazelnut, peanut and birch pollen is not always clear. We investigated whether IgE cross-reactivity between cashew nut-, hazelnut- and peanut proteins exists in children that are multi-allergic to these foods using a novel IMMULITE®-based inhibition methodology, and investigated which allergens might be responsible. In addition, we explored if an allergy to birch pollen might play a role in this cosensitisation for cashew nut, hazelnut and peanut.
Methods: Serum of five children with a confirmed cashew nut allergy and suffering from allergic symptoms after eating peanut and hazelnut were subjected to inhibition immunoassays using the IMMULITE® 2000 Xpi... View More»