Clinical & Experimental Cardiology
Open Access

Mardi Gomberg-Maitland

Publications

• Research Article
  A Serial NT-proBNP Model to Improve Prognostication in Patients with Pulmonary Arterial Hypertension
  Author(s): Aaron M Wolfson, Michael L Maitland, Vasiliki Thomeas, Cherylanne Glassner and Mardi Gomberg-Maitland Aaron M Wolfson, Michael L Maitland, Vasiliki Thomeas, Cherylanne Glassner and Mardi Gomberg-Maitland
  
  Background: Baseline elevation in N-terminal pro-brain natriuretic peptide (NT-proBNP) in pulmonary arterial hypertension (PAH) patients is associated with worse outcomes. Serial measurement of commonly available biomarkers could improve the precision of prognostic estimates and our understanding of PAH pathophysiology. Methods: Included were 103 PAH patients with baseline elevated NT-proBNP prior to the initiation or escalation of therapy with at least two subsequent NT-proBNP measurements. Using patients’ serial measurements, a linear mixed-effects model extrapolated a baseline NT-proBNP (intercept) and evolution (slope). These model-determined values were then used in Cox proportional hazards analysis to determine predictors of survival. Time-dependent area under the curve (AUC) analysis compared survival discrimination of serial versu.. View More»
  DOI: 10.4172/2155-9880.1000555

  Abstract PDF

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