Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Margaret Simonian
Los Angeles (UCLA), 611 Charles E. Young Drive East, CA, 90095
Tanzania
Research Article
Proteomics Analysis of Brain Meningiomas in Pursuit of Novel Biomarkers
of the Aggressive Behavior
Author(s): Garni Barkhoudarian, Julian P Whitelegge, Daniel F Kelly and Margaret Simonian
Garni Barkhoudarian, Julian P Whitelegge, Daniel F Kelly and Margaret Simonian
The aim of this pilot study was to evaluate the use of advanced proteomics techniques to identify novel protein markers that contribute to the transformation of benign meningiomas to more aggressive and malignant subtypes. Multiplex peptide stable isotope dimethyl labelling and nano LC-MS was used to identify and quantify the differentially expressed proteins in WHO Grade I, II and III meningioma tissues. The proteins identified will help elucidate the process of transformation to malignancy and may contribute to improved diagnosis and treatment of these aggressive tumors.
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DOI:
10.4172/jpb.1000389